| 5 Nov | MD E Shore 46 | at | Penn St 84 | vs MEAC | ||
| 9 Nov | Wagner 64 | at | Penn St 91 | vs NEC | ||
| 14 Nov | Penn St 81 | at | Georgetown 66 | at BE | ||
| 19 Nov | Bucknell 70 | at | Penn St 98 | vs PL | ||
| 23 Nov | Yale 56 | at | Penn St 58 | vs Ivy | ||
| 27 Nov | Mississippi 74 | vs | Penn St 72 | Brooklyn, NY | vs SEC | |
| 29 Nov | Penn St 85 | vs | Syracuse 64 | Brooklyn, NY | vs ACC | |
| 4 Dec | Wake Forest 54 | at | Penn St 76 | vs ACC | ||
| 7 Dec | Penn St 74 | at | Ohio St 106 | |||
| 10 Dec | Maryland 69 | at | Penn St 76 | |||
| 14 Dec | Alabama 71 | at | Penn St 73 | vs SEC | ||
| 20 Dec | Central Conn 58 | at | Penn St 87 | vs NEC | ||
| 29 Dec | Cornell 59 | at | Penn St 90 | vs Ivy | ||
| 4 Jan | Penn St 89 | vs | Iowa 86 | Philadelphia, PA | ||
| 7 Jan | Penn St 61 | at | Rutgers 72 | |||
| 11 Jan | Wisconsin 58 | at | Penn St 49 | |||
| 15 Jan | Penn St 69 | at | Minnesota 75 | |||
| 18 Jan | Ohio St | at | Penn St | |||
| 22 Jan | Penn St | at | Michigan | |||
| 29 Jan | Indiana | at | Penn St | |||
| 1 Feb | Penn St | at | Nebraska | |||
| 4 Feb | Penn St | at | Michigan St | |||
| 8 Feb | Minnesota | at | Penn St | |||
| 11 Feb | Penn St | at | Purdue | |||
| 15 Feb | Northwestern | at | Penn St | |||
| 18 Feb | Illinois | at | Penn St | |||
| 23 Feb | Penn St | at | Indiana | |||
| 26 Feb | Rutgers | at | Penn St | |||
| 29 Feb | Penn St | at | Iowa | |||
| 3 Mar | Michigan St | at | Penn St | |||
| 7 Mar | Penn St | at | Northwestern |
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