| 5 Nov | SC Upstate 55 | at | Col Charleston 74 | at CAA | ||
| 8 Nov | Truett-McConnell 62 | at | SC Upstate 103 | vs ND1 | ||
| 11 Nov | SC Upstate 64 | at | NC Central 73 | at MEAC | ||
| 13 Nov | SC Upstate 57 | at | Virginia Tech 80 | at ACC | ||
| 18 Nov | SC Upstate 45 | at | Akron 76 | at MAC | ||
| 20 Nov | SC Upstate 50 | at | Louisville 76 | at ACC | ||
| 23 Nov | Youngstown St 66 | at | SC Upstate 61 | vs HL | ||
| 30 Nov | SC Upstate 47 | at | Charlotte 83 | at CUSA | ||
| 3 Dec | E Kentucky 67 | at | SC Upstate 79 | vs OVC | ||
| 8 Dec | SC Upstate 72 | at | Furman 84 | at SC | ||
| 18 Dec | SC Upstate 73 | at | S Carolina St 70 | at MEAC | ||
| 21 Dec | Bob Jones 74 | at | SC Upstate 92 | vs ND1 | ||
| 29 Dec | VMI 82 | at | SC Upstate 91 | vs SC | ||
| 2 Jan | SC Upstate 75 | at | Charleston So 89 | |||
| 4 Jan | SC Upstate 73 | at | Longwood 56 | |||
| 8 Jan | Hampton 73 | at | SC Upstate 83 | |||
| 16 Jan | Radford 63 | at | SC Upstate 59 | |||
| 18 Jan | SC Upstate | at | Gardner Webb | |||
| 20 Jan | High Point | at | SC Upstate | |||
| 23 Jan | SC Upstate | at | Winthrop | |||
| 25 Jan | UNC Asheville | at | SC Upstate | |||
| 30 Jan | SC Upstate | at | Presbyterian | |||
| 1 Feb | Campbell | at | SC Upstate | |||
| 6 Feb | SC Upstate | at | UNC Asheville | |||
| 8 Feb | Gardner Webb | at | SC Upstate | |||
| 10 Feb | Charleston So | at | SC Upstate | |||
| 15 Feb | SC Upstate | at | High Point | |||
| 20 Feb | Longwood | at | SC Upstate | |||
| 22 Feb | SC Upstate | at | Radford | |||
| 27 Feb | Winthrop | at | SC Upstate | |||
| 29 Feb | SC Upstate | at | Hampton |
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