| 22-Feb | Wright St | 1 | at | Vanderbilt | 14 | ||
| 22-Feb | Wright St | 0 | at | Vanderbilt | 1 | ||
| 24-Feb | WKU | 1 | at | Vanderbilt | 12 | ||
| 26-Feb | Georgia St | 4 | at | Vanderbilt | 2 | ||
| 27-Feb | Georgia St | 4 | at | Vanderbilt | 5 | ||
| 28-Feb | Georgia St | 6 | at | Vanderbilt | 17 | ||
| 28-Feb | Georgia St | 2 | at | Vanderbilt | 12 | ||
| 5-Mar | IL Chicago | 0 | at | Vanderbilt | 15 | ||
| 6-Mar | IL Chicago | 2 | at | Vanderbilt | 5 | ||
| 7-Mar | IL Chicago | 2 | at | Vanderbilt | 4 | ||
| 9-Mar | Memphis | 4 | at | Vanderbilt | 10 | ||
| 13-Mar | Vanderbilt | 18 | at | Oklahoma St | 4 | ||
| 13-Mar | Vanderbilt | 5 | at | Oklahoma St | 0 | ||
| 14-Mar | Vanderbilt | 6 | at | Oklahoma St | 10 | ||
| 16-Mar | Belmont | 1 | at | Vanderbilt | 4 | ||
| 19-Mar | South Carolina | 2 | at | Vanderbilt | 3 | ||
| 20-Mar | South Carolina | 0 | at | Vanderbilt | 5 | ||
| 21-Mar | South Carolina | 6 | at | Vanderbilt | 5 | ||
| 23-Mar | Lipscomb | 3 | at | Vanderbilt | 11 | ||
| 25-Mar | Vanderbilt | 10 | at | Missouri | 2 | ||
| 26-Mar | Vanderbilt | 11 | at | Missouri | 3 | ||
| 27-Mar | Vanderbilt | 3 | at | Missouri | 1 | ||
| 30-Mar | Tennessee Tech | 5 | at | Vanderbilt | 12 | ||
| 1-Apr | Vanderbilt | 13 | at | LSU | 1 | ||
| 2-Apr | Vanderbilt | 11 | at | LSU | 2 | ||
| 3-Apr | Vanderbilt | 5 | at | LSU | 4 | ||
| 6-Apr | TN Martin | 4 | at | Vanderbilt | 5 | ||
| 8-Apr | Georgia | 14 | at | Vanderbilt | 2 | ||
| 9-Apr | Georgia | 2 | at | Vanderbilt | 5 | ||
| 10-Apr | Georgia | 9 | at | Vanderbilt | 1 | ||
| 13-Apr | E Kentucky | 4 | at | Vanderbilt | 6 | ||
| 16-Apr | Vanderbilt | 5 | at | Tennessee | 0 | ||
| 17-Apr | Vanderbilt | 4 | at | Tennessee | 8 | ||
| 18-Apr | Vanderbilt | 10 | at | Tennessee | 4 | ||
| 20-Apr | Austin Peay | 0 | at | Vanderbilt | 7 | ||
| 23-Apr | Mississippi St | 2 | at | Vanderbilt | 6 | ||
| 24-Apr | Mississippi St | 7 | at | Vanderbilt | 4 | ||
| 25-Apr | Mississippi St | 4 | at | Vanderbilt | 7 | ||
| 30-Apr | Vanderbilt | 11 | at | Florida | 7 | ||
| 1-May | Vanderbilt | 8 | at | Florida | 11 | ||
| 2-May | Vanderbilt | 3 | at | Florida | 5 | ||
| 4-May | Vanderbilt | 2 | at | Louisville | 7 | ||
| 7-May | Alabama | 6 | at | Vanderbilt | 9 | ||
| 8-May | Alabama | 2 | at | Vanderbilt | 6 | ||
| 11-May | North Alabama | 2 | at | Vanderbilt | 3 | ||
| 14-May | Vanderbilt | 1 | at | Mississippi | 3 | Oxford Miss. | |
| 15-May | Vanderbilt | 13 | at | Mississippi | 2 | ||
| 16-May | Vanderbilt | 10 | at | Mississippi | 13 | ||
| 18-May | Florida Intl | 4 | at | Vanderbilt | 20 | ||
| 20-May | Kentucky | 2 | at | Vanderbilt | 4 | ||
| 21-May | Kentucky | 2 | at | Vanderbilt | 8 | ||
| 22-May | Kentucky | 7 | at | Vanderbilt | 5 | ||
| 26-May | Vanderbilt | 5 | vs | Mississippi | 4 | Hoover AL | |
| 27-May | Arkansas | 6 | vs | Vanderbilt | 4 | Hoover AL | |
| 28-May | Mississippi | 4 | vs | Vanderbilt | 1 | Hoover AL | |
| 4-Jun | Presbyterian | 0 | vs | Vanderbilt | 10 | Nashville Regional | |
| 5-Jun | Georgia Tech | 3 | vs | Vanderbilt | 4 | Nashville Regional | |
| 6-Jun | Vanderbilt | 14 | vs | Georgia Tech | 11 | Nashville Regional (Vanderbilt advances) | |
| 11-Jun | East Carolina | 0 | vs | Vanderbilt | 2 | Nashville | |
| 12-Jun | Vanderbilt | 4 | vs | East Carolina | 1 | Nashville (Vanderbilt to CWS) | |
| 19-Jun | Arizona | 6 | vs | Vanderbilt | 7 | CWS #5 vs #4 | |
| 21-Jun | Vanderbilt | 0 | vs | NC State | 1 | Bracket 1 game 4 | |
| 23-Jun | Stanford | 5 | vs | Vanderbilt | 6 | Bracket 1 elimination game | |
| 25-Jun | Vanderbilt | 3 | vs | NC State | 1 | Bracket 1 Game 6 | |
| 26-Jun | NC State | 0 | vs | Vanderbilt | 1 | "Bracket 1 Game 7 (no contest, Covid)" | |
| 28-Jun | Mississippi St | 2 | vs | Vanderbilt | 8 | "CWS Finals, game 1" | |
| 29-Jun | Vanderbilt | 2 | vs | Mississippi St | 13 | "CWS Finals, game 2" | |
| 30-Jun | Mississippi St | 9 | vs | Vanderbilt | 0 | CWS Championship |