| 5 Nov | Kennesaw 55 | at | Creighton 81 | vs ASUN | ||
| 12 Nov | Creighton 69 | at | Michigan 79 | at B10 | ||
| 16 Nov | Louisiana Tech 72 | at | Creighton 82 | vs CUSA | ||
| 22 Nov | Cal Poly 70 | at | Creighton 86 | vs BWC | ||
| 24 Nov | North Florida 67 | at | Creighton 76 | vs ASUN | ||
| 28 Nov | San Diego St 83 | vs | Creighton 52 | Las Vegas, NV | vs MWC | |
| 29 Nov | Creighton 83 | vs | Texas Tech 76 | OT | Las Vegas, NV | vs B12 |
| 3 Dec | Oral Roberts 60 | at | Creighton 72 | vs SL | ||
| 7 Dec | Nebraska 76 | at | Creighton 95 | vs B10 | ||
| 13 Dec | UTRGV 58 | at | Creighton 89 | vs WAC | ||
| 17 Dec | Oklahoma 73 | at | Creighton 83 | vs B12 | ||
| 21 Dec | Creighton 67 | at | Arizona St 60 | at P12 | ||
| 28 Dec | Midland NE 54 | at | Creighton 91 | vs ND1 | ||
| 1 Jan | Marquette 75 | at | Creighton 92 | |||
| 4 Jan | Creighton 57 | at | Butler 71 | |||
| 7 Jan | Villanova 64 | at | Creighton 59 | |||
| 11 Jan | Creighton 77 | at | Xavier 65 | |||
| 15 Jan | Creighton 80 | at | Georgetown 83 | |||
| 18 Jan | Providence | at | Creighton | |||
| 22 Jan | Creighton | at | DePaul | |||
| 26 Jan | Xavier | at | Creighton | |||
| 1 Feb | Creighton | at | Villanova | |||
| 5 Feb | Creighton | at | Providence | |||
| 8 Feb | St John's | at | Creighton | |||
| 12 Feb | Creighton | at | Seton Hall | |||
| 15 Feb | DePaul | at | Creighton | |||
| 18 Feb | Creighton | at | Marquette | |||
| 23 Feb | Butler | at | Creighton | |||
| 1 Mar | Creighton | at | St John's | |||
| 4 Mar | Georgetown | at | Creighton | |||
| 7 Mar | Seton Hall | at | Creighton |
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