| 5 Nov | Alcorn St 54 | at | DePaul 72 | vs SWAC | ||
| 6 Nov | Chicago 55 | at | DePaul 84 | vs ND1 | ||
| 8 Nov | F Dickinson 59 | at | DePaul 70 | vs NEC | ||
| 11 Nov | DePaul 93 | at | Iowa 78 | at B10 | ||
| 16 Nov | Cornell 54 | at | DePaul 75 | vs Ivy | ||
| 23 Nov | DePaul 72 | at | Boston College 67 | at ACC | ||
| 26 Nov | C Michigan 75 | at | DePaul 88 | vs MAC | ||
| 29 Nov | DePaul 73 | at | Minnesota 68 | at B10 | ||
| 4 Dec | Texas Tech 60 | at | DePaul 65 | OT | vs B12 | |
| 8 Dec | Buffalo 74 | at | DePaul 69 | vs MAC | ||
| 14 Dec | IL Chicago 65 | at | DePaul 86 | vs HL | ||
| 18 Dec | DePaul 73 | at | Cleveland St 65 | at HL | ||
| 21 Dec | Northwestern 78 | at | DePaul 83 | vs B10 | ||
| 30 Dec | Seton Hall 74 | at | DePaul 66 | |||
| 4 Jan | Providence 66 | at | DePaul 65 | |||
| 11 Jan | DePaul 67 | at | St John's 74 | |||
| 14 Jan | DePaul 75 | at | Villanova 79 | OT | ||
| 18 Jan | Butler | at | DePaul | |||
| 22 Jan | Creighton | at | DePaul | |||
| 25 Jan | St John's | at | DePaul | |||
| 29 Jan | DePaul | at | Seton Hall | |||
| 1 Feb | DePaul | at | Marquette | |||
| 4 Feb | Xavier | at | DePaul | |||
| 8 Feb | DePaul | at | Georgetown | |||
| 15 Feb | DePaul | at | Creighton | |||
| 19 Feb | Villanova | at | DePaul | |||
| 22 Feb | Georgetown | at | DePaul | |||
| 25 Feb | DePaul | at | Xavier | |||
| 29 Feb | DePaul | at | Butler | |||
| 3 Mar | Marquette | at | DePaul | |||
| 7 Mar | DePaul | at | Providence |
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