| 5 Nov | MS Valley St 74 | at | Iowa St 110 | vs SWAC | ||
| 9 Nov | Iowa St 74 | at | Oregon St 80 | at P12 | ||
| 12 Nov | N Illinois 52 | at | Iowa St 70 | vs MAC | ||
| 19 Nov | Southern Miss 45 | at | Iowa St 73 | vs CUSA | ||
| 27 Nov | Michigan 83 | vs | Iowa St 76 | Nassau, Bahamas | vs B10 | |
| 28 Nov | Iowa St 104 | vs | Alabama 89 | Nassau, Bahamas | vs SEC | |
| 29 Nov | Seton Hall 84 | vs | Iowa St 76 | Nassau, Bahamas | vs BE | |
| 4 Dec | Missouri KC 61 | at | Iowa St 79 | vs WAC | ||
| 8 Dec | Seton Hall 66 | at | Iowa St 76 | vs BE | ||
| 12 Dec | Iowa 84 | at | Iowa St 68 | vs B10 | ||
| 22 Dec | PFW 59 | at | Iowa St 89 | vs SL | ||
| 31 Dec | Florida A&M 70 | at | Iowa St 68 | vs MEAC | ||
| 4 Jan | Iowa St 79 | at | TCU 81 | OT | ||
| 8 Jan | Kansas 79 | at | Iowa St 53 | |||
| 11 Jan | Oklahoma 68 | at | Iowa St 81 | |||
| 15 Jan | Iowa St 55 | at | Baylor 68 | |||
| 18 Jan | Iowa St | at | Texas Tech | |||
| 21 Jan | Oklahoma St | at | Iowa St | |||
| 25 Jan | Iowa St | at | Auburn | at SEC | ||
| 29 Jan | Baylor | at | Iowa St | |||
| 1 Feb | Iowa St | at | Texas | |||
| 5 Feb | Iowa St | at | West Virginia | |||
| 8 Feb | Kansas St | at | Iowa St | |||
| 12 Feb | Iowa St | at | Oklahoma | |||
| 15 Feb | Texas | at | Iowa St | |||
| 17 Feb | Iowa St | at | Kansas | |||
| 22 Feb | Texas Tech | at | Iowa St | |||
| 25 Feb | TCU | at | Iowa St | |||
| 29 Feb | Iowa St | at | Oklahoma St | |||
| 3 Mar | West Virginia | at | Iowa St | |||
| 7 Mar | Iowa St | at | Kansas St |
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